Tenovin-6 Hydrochloride
CAS No. 1011301-29-3
Tenovin-6 Hydrochloride ( —— )
Catalog No. M22048 CAS No. 1011301-29-3
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 42 | In Stock |
|
5MG | 58 | In Stock |
|
10MG | 72 | In Stock |
|
25MG | 129 | In Stock |
|
50MG | 214 | In Stock |
|
100MG | 356 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
|
Biological Information
-
Product NameTenovin-6 Hydrochloride
-
NoteResearch use only, not for human use.
-
Brief DescriptionTenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator.
-
DescriptionTenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a potent p53 activator .Inhibition of SIRT1/2 by Tenovin-6 induced apoptosis in UM cells by activating the expression of tumor suppressor genes such as p53 and elevating reactive oxygen species (ROS).?Tenovin-6 inhibited the growth of UM cells.?Tenovin-6 and vinblastine was synergistic in inducing apoptosis of UM cell line 92.1 and Mel 270.?Furthermore, Tenovin-6 eliminated cancer stem cells in 92.1 and Mel 270 cells.?In conclusion, our findings suggest that Tenovin-6 may be a promising agent to kill UM bulk tumor cells and CSCs.tenovin-6 increases microtubule-associated protein 1 light chain 3 (LC3-II) level in diverse cell types in a time- and dose-dependent manner. Mechanistically, the increase of LC3-II by tenovin-6 is caused by inhibition of the classical autophagy pathway via impairing lysosomal function without affecting the fusion between autophagosomes and lysosomes.tenovin-6 activation of p53 is cell type dependent, and tenovin-6 inhibition of autophagy is not dependent on its regulatory functions on p53 and SIRT1.
-
Synonyms——
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSIRT1;SIRT2;SIRT3;HDAC8;p53
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number1011301-29-3
-
Formula Weight491.09
-
Molecular FormulaC25H35ClN4O2S
-
Purity>98% (HPLC)
-
SolubilityDMSO:45 mg/mL (91.63 mM)
-
SMILESCl.CN(C)CCCCC(=O)NC1=CC=C(NC(=S)NC(=O)C2=CC=C(C=C2)C(C)(C)C)C=C1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Dai W, et al. Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma. Sci Rep. 2016 Mar 4;6:22622.2. Yuan H, et al. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017 Feb 9;8(2):e2608.
molnova catalog
related products
-
SirT1 enhancer A03
SirT1 enhancer A03 is a specific, orally bioavailable, brain penetrant apolipoprotein E4 (ApoE4)-targeted sirtuin1 (SirT1) enhancer.
-
Alogliptin
Alogliptin(SYR-322) is a potent, selective inhibitor of DPP-4 with IC50 of <10 nM, exhibits greater than 10, 000-fold selectivity over DPP-8 and DPP-9.
-
Octyl gallate
Octyl Gallate is an antioxidant approved by the US Food and Drug Administration (FDA) as a food additive. Octyl Gallate has antimetastatic activity.